A GABAB receptor antagonist
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CGP 36742

Item No. 35495

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-(3-aminopropyl)-P-butyl-phosphinic acid
CAS Number
123690-78-8
Synonyms
  • 3-Aminopropyl-n-butylphosphinic Acid
  • SGS 742
Molecular Formula
C7H18NO2P
Formula Weight
179.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
SMILES
O=P(CCCN)(CCCC)O
InChi Code
InChI=1S/C7H18NO2P/c1-2-3-6-11(9,10)7-4-5-8/h2-8H2,1H3,(H,9,10)
InChi Key
ONNMDRQRSGKZCN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $164

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    10 mg

    $295

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    25 mg

    $653

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    Product Description

    CGP 36742 is an antagonist of GABAB receptors (IC50 = 36 µM).1 It is selective for GABAB over a panel of 11 receptors, including GABAA, at 1 mM. CGP 36742 (3 mg/kg) reduces paired-pulse inhibition of the late inhibitory postsynaptic potential (IPSP) in CA1 pyramidal neurons in rats. It increases latency to step-down in a passive avoidance test in mice in a dose-dependent manner.2 CGP 36742 (10 and 30 mg/kg) decreases immobility time in the forced swim test in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olpe, H.R., Steinmann, M.W., Ferrat, T., et al. The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro. Eur. J. Pharmacol. 233(2-3), 179-186 (1993).

    2. Mondadori, C., Jaekel, J., and Preiswerk, G. CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys. Behav. Neural Biol. 60(1), 62-68 (1993).

    3. Nowak, G., Partyka, A., Palucha, A., et al. Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. Br. J. Pharmacol. 149(5), 581-590 (2006).