Kumatakenin

Kumatakenin is a flavonoid that has been found in S. aromaticum and has diverse biological activities.^1,2,3 It inhibits the growth of SKOV3 and A2780 ovarian cancer cells in a concentration-dependent manner.¹ It induces apoptosis and decreases the protein levels of the tumor-associated macrophage (TAM) recruitment factors MCP-1 and RANTES in SKOV3 cells when used at a concentration of 30 µM. Kumatakenin (10 µM) inhibits neutrophil elastase activity and inhibits antigen-induced RBL-2H3 mast cell degranulation (IC₅₀ = 80.4 µM).² It is active against S. aureus, E. coli, P. aeruginosa, and L. monocytogenes (MICs = 64, 128, 128, and 512 µg/ml, respectively) and acts synergistically with ampicillin (Item No. 14417), gentamicin, or erythromycin (Item No. 16486) to reduce L. monocytogenes biofilm formation.³

WARNING This product is not for human or veterinary use.

1. Woo, J.-H., Ahn, J.-H., Jang, D.S., et al. Effect of kumatakenin isolated from cloves on the apoptosis of cancer cells and the alternative activation of tumor-associated macrophages. J. Agric. Food Chem. 65(36), 7893-7899 (2017).

2. Ebada, S.S., Al-Jawabri, N.A., Youssef, F.S., et al. Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: Identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses. RSC Adv. 10(62), 38128-38141 (2020).

3. Zhang, X., Wang, L., Mu, H., et al. Synergistic antibacterial effects of Buddleja albiflora metabolites with antibiotics against Listeria monocytogenes. Lett. Appl. Microbiol. 68(1), 38-47 (2019).