An EGFR inhibitor
Related Products
Alternative(s)
10483Erlotinib
Labeled Version(s)
22101Erlotinib-d6 (hydrochloride)
Metabolite(s)
23394Desmethyl Erlotinib
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Erlotinib (hydrochloride)

Item No. 35517

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, monohydrochloride
CAS Number
183319-69-9
Synonyms
  • CP 358,774
  • NSC 718781
  • OSI-774
Molecular Formula
C22H23N3O4 • HCl
Formula Weight
429.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
222, 246, 345 nm
SMILES
COCCOC(C=C1C(NC2=CC=CC(C#C)=C2)=NC=NC1=C3)=C3OCCOC.Cl
InChi Code
InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
InChi Key
GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Erlotinib is an EGFR inhibitor (Ki = 2.7 nM).1 It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM.2 Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM.3 Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model.2 Formulations containing erlotinib have been used in the treatment of various cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ciardiello, F., and Tortora, G. A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor. Clin. Cancer Res. 7(10), 2958-2970 (2001).

    2. Moyer, J.D., Barbacci, E.G., Iwata, K.K., et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57(21), 4838-4848 (1997).

    3. Herbst, R.S., and Bunn, P.A., Jr. Targeting the epidermal growth factor receptor in non-small cell lung cancer. Clin. Cancer Res. 9(16), 5813-5824 (2003).