An organoarsenic compound
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Phenylarsine Oxide

Item No. 35525

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
oxophenyl-arsine
CAS Number
637-03-6
Synonyms
  • NSC 42470
Molecular Formula
C6H5AsO
Formula Weight
168.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble
λmax
221 nm
SMILES
O=[As]C1=CC=CC=C1
InChi Code
InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
InChi Key
BQVCCPGCDUSGOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    250 mg

    $32

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    500 mg

    $61

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    1 g

    $75

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Phenylarsine oxide is an organoarsenic compound.1 It inhibits insulin-induced protein phosphatase 1 (PP1) activity and glucose transporter 4 (Glut4) translocation in rat adipocytes when used at a concentration of 5 µM. Phenylarsine oxide completely inhibits insulin-induced PI3K activation and glucose transport in 3T3-L1 adipocytes when used at concentrations of 30 and 50 µM, respectively.2 It inhibits potassium chloride-induced exocytosis and induces mitochondrial depolarization in isolated rat brain synaptosomes.3 Phenylarsine oxide (0.3 and 1 mg/kg, i.p.) reduces LPS-induced neutrophil infiltration in bronchoalveolar lavage fluid (BALF) and carrageenan-induced paw edema in rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Begum, N. Phenylarsine oxide inhibits insulin-stimulated protein phosphatase 1 activity and GLUT-4 translocation. Am. J. Physiol. 267(1 Pt. 1), E14-E23 (1994).

    2. Han, Y.P., and Kohanski, R.A. Phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase. Biochem. Biophys. Res. Commun. 239(1), 316-321 (1997).

    3. Tarasenko, A.S., Kostrzhevska, O.G., Storchak, L.G., et al. Phenylarsine oxide is able to dissipate synaptic vesicle acidic pool. Neurochem. Int. 46(7), 541-550 (2005).

    4. Roussin, A., Cabec, V.L., Lonchampt, M., et al. Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsine oxide. Eur. J. Pharmacol. 322(1), 91-96 (1997).