An allosteric SIRT6 activator
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MDL 800

Item No. 35528

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-benzoic acid, methyl ester
CAS Number
2275619-53-7
Molecular Formula
C21H16BrCl2FN2O6S2
Formula Weight
626.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/ml
SMILES
CC1=C(NS(C2=C(C(OC)=O)C=C(NS(C3=CC(Cl)=CC(Cl)=C3)(=O)=O)C=C2)(=O)=O)C=C(Br)C(F)=C1
InChi Code
InChI=1S/C21H16BrCl2FN2O6S2/c1-11-5-18(25)17(22)10-19(11)27-35(31,32)20-4-3-14(9-16(20)21(28)33-2)26-34(29,30)15-7-12(23)6-13(24)8-15/h3-10,26-27H,1-2H3
InChi Key
FKFQBYBODAKGOA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $98

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    25 mg

    $233

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    50 mg

    $381

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    Product Description

    MDL 800 is an allosteric activator of sirtuin 6 (SIRT6).1 It selectively activates SIRT6 deacetylase activity over SIRT1-5 and -7 and histone deacetylase 1 (HDAC1) and HDAC2-11 deacetylase activity in cell-free assays at 100 µM. It induces histone deacetylation (IC50 = 23.3 µM) in, and reduces proliferation of, BEL-7405 hepatocellular carcinoma (HCC) cells (EC50 = 90.4 µM). MDL 800 (0.1-5 µM) inhibits TNF-α release induced by oxygen and glucose deprivation (OGD) in primary mouse microglia.2 In vivo, MDL 800 (50, 100, and 150 mg/kg) reduces tumor weight and volume in a BEL-7405 HCC mouse xenograft model.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, Z., Zhao, J., Deng, W., et al. Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol. 14(12), 1118-1126 (2018).

    2. He, T., Shang, J., Gao, C., et al. A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis. Acta Pharm. Sin. B 11(3), 708-726 (2021).