A CD38 inhibitor
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CD38 Inhibitor 1

Item No. 35532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone
CAS Number
1700637-55-3
Synonyms
  • CD38-IN-78c
  • CD38 Inhibitor 78c
Molecular Formula
C22H27N3O3S
Formula Weight
413.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
221, 290 nm
SMILES
CN1C2=CC=C(C3=CN=CS3)C=C2C(N[C@@H]4CC[C@H](CC4)OCCOC)=CC1=O
InChi Code
InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChi Key
VJQALSOBHVEJQM-QAQDUYKDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    CD38 inhibitor I is an inhibitor of CD38 (IC50 = 17.7 nM).1 It is selective for CD38 over poly(ADP-ribose) polymerase 1 (PARP1), sirtuin 1 (SIRT1), and nicotinamide phosphoribosyltransferase (Nampt) when used at a concentration of 100 nM. CD38 inhibitor I (200 nM) increases NAD+ levels in mouse embryonic fibroblasts (MEFs). It decreases glucose and insulin levels in an intraperitoneal glucose tolerance test in 2-year-old, but not 1-year-old or 3-month-old, mice when administered at a dose of 10 mg/kg twice per day. CD38 inhibitor I prevents age-dependent decreases in exercise capacity and physical activity and increases in DNA damage in liver and skeletal muscle in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tarragó, M.G., Chini, C.C.S., Kanamori, K.S., et al. A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD+ decline. Cell Metab. 27(5), 1081-1095e1010 (2018).