A thalidomide derivative with teratogenic activity
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EM-12

Item No. 35555

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
CAS Number
26581-81-7
Molecular Formula
C13H12N2O3
Formula Weight
244.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 1 mg/ml
λmax
229 nm
SMILES
O=C1NC(C(CC1)N2C(C3=CC=CC=C3C2)=O)=O
InChi Code
InChI=1S/C13H12N2O3/c16-11-6-5-10(12(17)14-11)15-7-8-3-1-2-4-9(8)13(15)18/h1-4,10H,5-7H2,(H,14,16,17)
InChi Key
WENKGSGGXGQHSH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    EM-12 is a derivative of thalidomide (Item No. 14610) with teratogenic activity.1 Intravenous administration of EM-12 (150 mg/kg) to pregnant females induces fetal resorption and skeletal malformation in surviving offspring in rats, rabbits, and rhesus monkeys. Dietary administration of EM-12 (12% w/w) enhances 1,2-dimethylhydrazine-induced colonic adenocarcinoma formation in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schumacher, H.J., Terapane, J., Jordan, R.L., et al. The teratogenic activity of a thalidomide analogue, EM12 in rabbits, rats, and monkeys. Teratology 5(2), 233-240 (1972).

    2. Gershbein, L.L. The thalidomide analog, EM 12, enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. Cancer Lett. 60(2), 129-133 (1991).