A racemic mixture of of L-norepinephrine and D-norepinephrine
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(±)-Norepinephrine (hydrochloride)

Item No. 35580

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, monohydrochloride
CAS Number
55-27-6
Synonyms
  • (±)-Arterenol
  • DL-Noradrenaline
  • DL-Norepinephrine
  • (±)-Noradrenaline
  • NSC 7930
Molecular Formula
C8H11NO3 • HCl
Formula Weight
205.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC1=C(O)C=C(C(CN)O)C=C1.Cl
InChi Code
InChI=1S/C8H11NO3.ClH/c9-4-8(12)5-1-2-6(10)7(11)3-5;/h1-3,8,10-12H,4,9H2;1H
InChi Key
FQTFHMSZCSUVEU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $33

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    100 mg

    $60

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    250 mg

    $139

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    500 mg

    $258

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    Product Description

    (±)-Norepinephrine is a racemic mixture of the endogenous neurotransmitter (–)-norepinephrine (Item No. 16673) and (+)-norepinephrine. It induces cAMP accumulation in rat cerebral cortical membranes when used at concentrations ranging from 1 to 100 µM.1 (±)-Norepinephrine induces contraction of bovine anterior cerebral, middle cerebral, and internal carotid arterial strips (EC50s = 0.91, 0.92, and 0.87 µM, respectively) but induces relaxation of bovine posterior cerebral arterial strips (EC50 = 0.95 µM).2 Formulations containing (±)-norepinephrine have been used for the restoration of blood pressure in acute hypotensive states.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tadokoro, C., Kiuchi, Y., Yamazaki, Y., et al. Behavioral stimulation without alteration of β and 5-HT receptors and adenylate cyclase activity in rat brain after chronic sertraline administration. Psychopharmacology (Berl.) 130(2), 124-130 (1997).

    2. Ayajiki, K., and Toda, N. Isolated bovine cerebral arteries from rostral and caudal regions: Distinct responses to adrenoceptor agonists. Eur. J. Pharmacol. 191(3), 417-425 (1990).