A cardiac glycoside with cytotoxic and cardiac modulatory activities
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Isomer(s)
29871Oleandrin
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Cerberin

Item No. 35582

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,5β)-3-[(2-O-acetyl-6-deoxy-3-O-methyl-α-L-glucopyranosyl)oxy]-14-hydroxy-card-20(22)-enolide
CAS Number
25633-33-4
Synonyms
  • 2′-Acetylneriifolin
Molecular Formula
C32H48O9
Formula Weight
576.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C(CO4)=CC4=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)OC(C)=O)([H])CC3)C
InChi Code
InChI=1S/C32H48O9/c1-17-26(35)27(37-5)28(40-18(2)33)29(39-17)41-21-8-11-30(3)20(15-21)6-7-24-23(30)9-12-31(4)22(10-13-32(24,31)36)19-14-25(34)38-16-19/h14,17,20-24,26-29,35-36H,6-13,15-16H2,1-5H3/t17-,20+,21-,22+,23-,24+,26-,27+,28-,29-,30-,31+,32-/m0/s1
InChi Key
UYQMTWMXBKEHJQ-IVHDSYOHSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    2.5 mg

    $358

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    Cayman Chemical
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    Product Description

    Cerberin is a cardiac glycoside that has been found in C. odollam and has cytotoxic and cardiac modulatory activities.1,2 It is cytotoxic to KB and NCI H187 cancer cells (IC50s = 1.92 and 1.24 µg/ml).1 Cerberin inhibits Na+/K+-ATPase, increasing intracellular sodium levels and action potential duration in cardiac cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Laphookhieo, S., Cheenpracha, S., Karalai, C., et al. Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam. Phytochemistry 65(4), 507-510 (2004).

    2. Menezes, R.G., Usman, M.S., Hussain, S.A., et al. Cerbera odollam toxicity: A review. J. Forensic Leg. Med. 58, 113-116 (2018).