Oleandrin

Oleandrin is a glycoside that has been found in N. oleander and has diverse biological activities.^1,2,3,4 It inhibits NF-κB activation induced by hydrogen peroxide, LPS, okadaic acid (Item No. 10011490), ceramide, or TNF in U937 cells when used at a concentration of 1 µg/ml.¹ Oleandrin inhibits transmissible gastroenteritis virus (TGEV) replication without inducing cytotoxicity in swine testis cells (IC₅₀ = 147 nM).² It reduces pyramidal neuron cell death induced by oxygen-glucose deprivation (OGD) in cultured rat brain explant slices.³ Oleandrin reduces viability and inhibits migration of U87MG, A172, U251, and GBM19 glioma cells.⁴ In vivo, oleandrin (0.3 mg/kg) reduces tumor size and increases survival in U78MG, GL261, and U251 glioma mouse xenograft models.

WARNING This product is not for human or veterinary use.

1. Manna, S.K., Sah, N.K., Newman, R.A., et al. Oleandrin suppresses activation of nuclear transcription factor-κB, activator protein-1, and c-Jun NH2-terminal kinase. Cancer Res. 60(14), 3838-3847 (2000).

2. Yang, C.-W., Chang, H.-Y., Hsu, H.-Y., et al. Identification of anti-viral activity of the cardenolides, Na⁺/K⁺-ATPase inhibitors, against porcine transmissible gastroenteritis virus. Toxicol. Appl. Pharmacol. 332, 129-137 (2017).

3. Dunn, D.E., He, D.N., Yang, P., et al. In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. J. Neurochem. 119(4), 805-814 (2011).

4. Garofalo, S., Grimaldi, A., Chece, G., et al. The glycoside oleandrin reduces glioma growth with direct and indirect effects on tumor cells. J. Neurosci. 37(14), 3926-3939 (2017).