An internal standard for the quantification of paroxetine
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Unlabeled Version(s)
14998Paroxetine (hydrochloride)
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Paroxetine-d6 (hydrochloride)

Item No. 35603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl-d2]-4-(4-fluorophenyl)-piperidine-2,2,6,6-d4, monohydrochloride
Molecular Formula
C19H14D6FNO3 • HCl
Formula Weight
371.9
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
FC1=CC=C([C@H]2[C@H](C([2H])([2H])OC3=CC(OCO4)=C4C=C3)C([2H])([2H])NC([2H])([2H])C2)C=C1.Cl
InChi Code
InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1/i8D2,10D2,11D2;
InChi Key
GELRVIPPMNMYGS-UGESGLEFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $156

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    1 mg

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    Product Description

    Paroxetine-d6 is intended for use as an internal standard for the quantification of paroxetine (Item No. 14998) by GC- or LC-MS. Paroxetine is a selective serotonin reuptake inhibitor (SSRI; Ki = 0.04 nM).1 It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor, α1- and α2-adrenergic receptors (α2-ARs), and muscarinic acetylcholine receptors (mAChRs; Kis = 21,168, 6,320, 13,746, 995, 3,915, and 42 nM, respectively).1,2 Paroxetine (5 mg/kg) decreases immobility time in the forced swim test in mice.3 Formulations containing paroxetine have been used in the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, social and generalized anxiety disorders, and post-traumatic stress disorder (PTSD).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mattson, R.J., Catt, J.D., Denhart, D.J., et al. Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors. J. Med. Chem. 48(19), 6023-6034 (2005).

    2. Owens, M.J., Neal, W., Plott, S.J., et al. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J. Pharmacol. Exp. Ther. 283(3), 1305-1322 (1997).

    3. Sugimoto, Y., Tagawa, N., Kobayashi, Y., et al. Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine. Eur. J. Pharmacol. 696(1-3), 96-100 (2012).