A triterpenoid saponin and an antagonist of TRPA1
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Saikosaponin F

Item No. 35626

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,16β)-16,28-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside
CAS Number
62687-63-2
Molecular Formula
C48H80O17
Formula Weight
929.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetone: solubleChloroform: solubleDichloromethane: solubleDMSO: solubleEthyl Acetate: soluble
SMILES
C[C@@]12C([C@@]3([H])[C@@]([C@H](C2)O)(CCC(C)(C3)C)CO)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)CO[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C)C
InChi Code
InChI=1S/C48H80O17/c1-22-31(52)33(54)37(58)41(61-22)65-39-26(20-60-40-36(57)34(55)32(53)25(19-49)62-40)63-42(38(59)35(39)56)64-30-12-13-45(6)27(44(30,4)5)11-14-46(7)28(45)10-9-23-24-17-43(2,3)15-16-48(24,21-50)29(51)18-47(23,46)8/h9,22,24-42,49-59H,10-21H2,1-8H3/t22-,24-,25+,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38+,39+,40+,41-,42-,45-,46+,47+,48+/m0/s1
InChi Key
SXILFEBNQCRWAL-VERCZQKXSA-N
Origin
Plant/Bupleurum scorzonerifolium root
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $104

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    10 mg

    $165

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    Product Description

    Saikosaponin F is a triterpenoid saponin that has been found in B. chinensis and an antagonist of transient receptor potential ankyrin 1 (TRPA1).1 It inhibits calcium flux induced by polygodial (Item No. 14979) or AITC in HEK293 cells expressing human TRPA1 when used at concentrations ranging from 0.5 to 1.5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, G., Choi, J., Nam, Y.-J., et al. Identification and characterization of saikosaponins as antagonists of transient receptor potential A1 channel. Phytother Res. 34(4), 788-795 (2020).