A potential impurity found in commercial preparations of valsartan
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Desvaleryl Valsartan

Item No. 35634

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
CAS Number
676129-92-3
Synonyms
  • Valsartan Impurity B
Molecular Formula
C19H21N5O2
Formula Weight
351.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 1 mg/ml
SMILES
CC(C)[C@@H](C(O)=O)NCC1=CC=C(C=C1)C2=C(C3=NN=NN3)C=CC=C2
InChi Code
InChI=1S/C19H21N5O2/c1-12(2)17(19(25)26)20-11-13-7-9-14(10-8-13)15-5-3-4-6-16(15)18-21-23-24-22-18/h3-10,12,17,20H,11H2,1-2H3,(H,25,26)(H,21,22,23,24)/t17-/m0/s1
InChi Key
NSXSCTCKWRSTHJ-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $62

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Desvaleryl valsartan is a potential impurity found in commercial preparations of the angiotensin II type 1 (AT1) receptor antagonist valsartan.1 It is a degradation product formed under acidic conditions.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krishnaiah, C., Reddy, A.R., Kumar, R., et al. Stability-indicating UPLC method for determination of valsartan and their degradation products in active pharmaceutical ingredient and pharmaceutical dosage forms. J. Pharm. Biomed. Anal. 53(3), 483-489 (2010).

    2. Kumaraswamy, K., Gandham, H.B., Prasad, R.J.D., et al. Isolation and characterization of novel degradation products of valsartan by NMR and high resolution mass spectroscopy: Development and validation of valsartan by UPLC. Asian J. Chem. 32(5), 1064-1068 (2020).