An acetylated phenol with diverse biological activities
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Isomer(s)
374182'-Hydroxyacetophenone
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4-Acetylphenol

Item No. 35636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-hydroxyphenyl)-ethanone
CAS Number
99-93-4
Synonyms
  • 4-Hydroxyacetophenone
  • p-Hydroxyacetophenone
  • para-Hydroxyacetophenone
  • NSC 3698
  • Piceol
Molecular Formula
C8H8O2
Formula Weight
136.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 0.2 mg/ml
λmax
220, 278 nm
SMILES
O=C(C)C1=CC=C(C=C1)O
InChi Code
InChI=1S/C8H8O2/c1-6(9)7-2-4-8(10)5-3-7/h2-5,10H,1H3
InChi Key
TXFPEBPIARQUIG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-Acetylphenol is an acetylated phenol that has been found in P. abies and has diverse biological activities.1,2,3,4 It is active against C. cucumerinum, a plant-pathogenic fungus, when used at concentrations of 0.5, 1, and 2 mg/ml.1 4-Acetylphenol (147.1 and 294.1 µM) decreases hepatitis B virus (HBV) particle secretion from Huh7 cells.2 Its levels are increased in Norway spruce exhibiting dieback but not in healthy trees.3 Dietary administration of 4-acetylphenol, in combination with 3,4-hydroxy-acetophenone, reduces pupal survival and mass, as well as increases development time, in spruce budworms (C. fumiferana).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Osswald, W.F., Zieboll, S., Schütz, W., et al. p-Hydroxyacetophenone a fungitoxic compound in spruce needles. J. Plant Dis. Prot. 94(6), 572-577 (1987).

    2. Huang, T.-J., Liu, S.-H., Kuo, Y.-C., et al. Antiviral activity of chemical compound isolated from Artemisia morrisonensis against hepatitis B virus in vitro. Antiviral Res. 101, 97-104 (2014).

    3. Hoque, E. Norway spruce die-back: Isolation, biological activity, measurement of concentration of p-hydroxy acetophenone and its O-glucoside (Picein) by gas chromatography. Eur. J. For. Path. 14(6), 377-382 (1984).

    4. Delvas, N., Bauce, É., Labbé, C., et al. Phenolic compounds that confer resistance to spruce budworm. Entomol. Exp. Appl. 141(1), 35-44 (2011).