A derivative of L-tyrosine
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3-chloro-L-Tyrosine

Item No. 35753

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
7423-93-0
Synonyms
  • 3-Chlorotyrosine
  • 3-CT
Molecular Formula
C9H10ClNO3
Formula Weight
215.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleEthanol: Slightly solublePBS (pH 7.2): 1 mg/mL
SMILES
OC([C@@H](N)CC1=CC(Cl)=C(C=C1)O)=O
InChi Code
InChI=1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
InChi Key
ACWBBAGYTKWBCD-ZETCQYMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $46

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    1 g

    $85

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    5 g

    $246

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    Cayman Chemical
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    Product Description

    3-chloro-L-Tyrosine is a derivative of L-tyrosine.1 It is formed from a reaction between the myeloperoxidase (MPO) product hypochlorous acid and L-tyrosine and has been used as a biomarker of oxidative damage induced by MPO. Plasma and atherosclerotic plaque levels of 3-chloro-L-tyrosine are increased in patients with various cardiovascular diseases.2 Plasma levels of 3-chloro-L-tyrosine are also increased in patients with colorectal cancer. 3-chloro-L-Tyrosine is also formed in blood upon chlorine gas exposure and has been used as an indicator of chlorine poisoning during autopsy.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feeney, M.B., and Schöneich, C. Tyrosine modifications in aging. Antioxid. Redox Signal. 17(11), 1571-1579 (2012).

    2. Fleszar, M.G., Fortuna, P., Zawadzki, M., et al. Simultaneous LC-MS/MS-based quantification of free 3-nitro-l-tyrosine, 3-chloro-l-tyrosine, and 3-bromo-l-tyrosine in plasma of colorectal cancer patients during early postoperative period. Molecules 25(21), 5158 (2020).

    3. Nishio, T., Toukairin, Y., Hoshi, T., et al. Determination of 3-chloro-l-tyrosine as a novel indicator of chlorine poisoning utilizing gas chromatography-mass spectrometric analysis. Leg. Med. (Tokyo) 47, 101782 (2020).