An internal standard for the quantification of hesperetin
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Unlabeled Version(s)
10006084Hesperetin
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rac-Hesperetin-d3

Item No. 35802

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(3-hydroxy-4-(methoxy-d3)phenyl)chroman-4-one
CAS Number
1346605-26-2
Synonyms
  • (±)-3',5,7-Trihydroxy-4'-methoxyflavanone-d3
Molecular Formula
C16H11D3O6
Formula Weight
305.3
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
OC1=C(OC([2H])([2H])[2H])C=CC(C2CC(C3=C(O)C=C(O)C=C3O2)=O)=C1
InChi Code
InChI=1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/i1D3
InChi Key
AIONOLUJZLIMTK-FIBGUPNXSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $366

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    Product Description

    rac-Hesperetin-d3 is intended for use as an internal standard for the quantification of hesperetin (Item No. 10006084) by GC- or LC-MS. rac-Hesperetin is a racemic mixture of the flavanones (S)-hesperetin (Item No. 10006084) and (R)-hesperetin. rac-Hesperetin (1 mM) inhibits heat-induced advanced glycation end product formation between BSA and glucose by 56.7%.1 It also inhibits α-glucosidase and protein tyrosine phosphatase 1B (PTP1B; IC50s = 15.28 and 20.16 µM, respectively).2 rac-Hesperetin (100 µM) protects against hydrogen peroxide-induced cytotoxicity in MIN6 pancreatic beta cells by 72.27%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, D., Mitsuhashi, S., and Ubukata, M. Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation. Pharm. Biol. 50(12), 1531-1535 (2012).

    2. Xu, J., Wang, X., Yue, J., et al. Polyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells and their inhibitory activity against α-glucosidase and protein tyrosine phosphatase 1B. Molecules 23(9), 2167 (2018).