An OPN4 receptor antagonist
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AA92593

Item No. 35836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-methoxy-3-methylphenyl)sulfonyl]-piperidine
CAS Number
457961-34-1
Molecular Formula
C13H19NO3S
Formula Weight
269.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.20 mg/ml
λmax
242 nm
SMILES
O=S(C1=CC=C(C(C)=C1)OC)(N2CCCCC2)=O
InChi Code
InChI=1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3
InChi Key
HDTKLZINZGEPFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $82

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    10 mg

    $154

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    25 mg

    $303

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    50 mg

    $524

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    Product Description

    AA92593 is an opsin 4 (OPN4) receptor antagonist (Ki = 16 nM).1 It inhibits light-induced calcium transients in CHO cells expressing human OPN4 (IC50 = 665 nM). AA92593 (10 µM) reverses light-induced calcium influx in rat intrinsically photosensitive retinal ganglion cells (ipRGCs). In vivo, AA92593 (30 mg/kg) reduces light-induced pupil constriction in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, K.A., Hatori, M., Mure, L.S., et al. Small-molecule antagonists of melanopsin-mediated phototransduction. Nat. Chem. Biol. 9(10), 630-635 (2013).