An OPN4 receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

AA92593

Item No. 35836

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-methoxy-3-methylphenyl)sulfonyl]-piperidine
CAS Number
457961-34-1
Molecular Formula
C13H19NO3S
Formula Weight
269.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.20 mg/ml
λmax
242 nm
SMILES
O=S(C1=CC=C(C(C)=C1)OC)(N2CCCCC2)=O
InChi Code
InChI=1S/C13H19NO3S/c1-11-10-12(6-7-13(11)17-2)18(15,16)14-8-4-3-5-9-14/h6-7,10H,3-5,8-9H2,1-2H3
InChi Key
HDTKLZINZGEPFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $82

    Add

    10 mg

    $154

    Add

    25 mg

    $303

    Add

    50 mg

    $524

    Add
    Product Description

    AA92593 is an opsin 4 (OPN4) receptor antagonist (Ki = 16 nM).1 It inhibits light-induced calcium transients in CHO cells expressing human OPN4 (IC50 = 665 nM). AA92593 (10 µM) reverses light-induced calcium influx in rat intrinsically photosensitive retinal ganglion cells (ipRGCs). In vivo, AA92593 (30 mg/kg) reduces light-induced pupil constriction in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jones, K.A., Hatori, M., Mure, L.S., et al. Small-molecule antagonists of melanopsin-mediated phototransduction. Nat. Chem. Biol. 9(10), 630-635 (2013).