Pomiferin

Pomiferin is a flavonoid that has been found in M. pomifera and has diverse biological activities.^1,2,3 It scavenges peroxynitrite and DPPH (Item No. 14805) radicals in cell-free assays when used at concentrations of 250 and 7 µM, respectively, and inhibits Fe(II)/NADPH-induced lipid peroxidation in rat liver microsomes at 10 µM.¹ Pomiferin is cytotoxic to HeLa, Hep3B, HepG2, H1299, MCF-7, and LNCaP cancer cells (IC₅₀s = 13.56-22.36 µM) and induces the formation of autophagic puncta in HeLa cells when used at a concentration of 10 µM.² In vivo, pomiferin (25 and 50 mg/kg) reduces tumor volume and the number of lung metastases in a murine Lewis lung carcinoma model. It also improves pulmonary function, increases survival, and decreases lung levels of TNF-α and IL-1β in a mouse model of LPS-induced acute respiratory distress syndrome (ARDS).³

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1. Veselá, D., Kubínová, R., Muselík, J., et al. Antioxidative and EROD activities of osajin and pomiferin. Fitoterapia 75(2), 209-211 (2004).

2. Qu, Y.-Q., Song, L.-L., Xu, S.-W., et al. Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo. Pharmacol. Res. 191, 106769 (2023).

3. Tang, Z., Yang, Z., Feng, H., et al. Attenuation of the severity of acute respiratory distress syndrome by pomiferin through blocking inflammation and oxidative stress in an AKT/Foxo1 pathway-dependent manner. Oxid. Med. Cell. Longev. 5236908 (2022).