A CGRP receptor antagonist
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Atogepant

Item No. 35899

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3′S)-1′,2′,5,7-tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)-3-piperidinyl]-2′-oxo-spiro[6H-cyclopenta[b]pyridine-6,3′-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide
CAS Number
1374248-81-3
Molecular Formula
C29H23F6N5O3
Formula Weight
603.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C1[C@]2(CC3=CC(C(N[C@H]4C[C@@H](C5=C(C(F)=CC=C5F)F)[C@H](N(C4=O)CC(F)(F)F)C)=O)=CN=C3C2)C6=CC=CN=C6N1
InChi Code
InChI=1S/C29H23F6N5O3/c1-13-16(22-18(30)4-5-19(31)23(22)32)8-20(26(42)40(13)12-29(33,34)35)38-25(41)15-7-14-9-28(10-21(14)37-11-15)17-3-2-6-36-24(17)39-27(28)43/h2-7,11,13,16,20H,8-10,12H2,1H3,(H,38,41)(H,36,39,43)/t13-,16-,20+,28+/m1/s1
InChi Key
QIVUCLWGARAQIO-OLIXTKCUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $208

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    Product Description

    Atogepant is an antagonist of the calcitonin gene-related peptide (CGRP) receptor (IC50 = 0.026 nM).1 It is selective for the CGRP receptor over the adrenomedullin receptors (AM1) and AM2, calcitonin (CT) receptor, amylin receptor 1 (AMY1), and AMY3 receptor (IC50s = >18,000, 400, 6,274, 2.4 and 1,418 nM, respectively). Atogepant (3-30 mg/kg) increases the mechanical pain threshold in the von Frey test in a rat model of nitroglycerin-induced migraine. Formulations containing atogepant have been used in the prevention of episodic migraines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Moore, E., Bell, I.M., Fraley, M.E., et al. Pharmacologic characterization of atogepant: A potent and selective calcitonin gene-related peptide receptor antagonist. Cephalalgia 44(1), 3331024231226186 (2024).