A flavanone glucoside with diverse biological activities
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Isomer(s)
28267Astilbin
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Eriodictyol 7-O-glucoside

Item No. 36003

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-(3,4-dihydroxyphenyl)-7-(β-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one
CAS Number
38965-51-4
Synonyms
  • 7-O-β-D-Glucopyranosyl-eriodictyol
  • (2S)-Eriodictyol 7-O-β-D-glucopyranoside
Molecular Formula
C21H22O11
Formula Weight
450.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10mM
λmax
283 nm
SMILES
OC1=C2C(O[C@@H](CC2=O)C3=CC(O)=C(O)C=C3)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1
InChi Code
InChI=1S/C21H22O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-5,14,16,18-25,27-29H,6-7H2/t14-,16+,18+,19-,20+,21+/m0/s1
InChi Key
RAFHNDRXYHOLSH-SFTVRKLSSA-N
Origin
Plant/Viscμm articulatum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Eriodictyol 7-O-glucoside is a flavanone glucoside that has been found in V. coloratum and has diverse biological activities.1,2,3 It scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively).1 Eriodictyol 7-O-glucoside activates nuclear factor E2-related factor 2 (Nrf2) in a reporter assay.2 It protects against cytotoxicity induced by cisplatin (Item No. 13119) in human renal mesangial cells (HRMCs), but not A549 lung or MDA-MB-231 breast cancer cells, when used at a concentration of 80 µM. Eriodictyol 7-O-glucoside (30 mg/kg) attenuates neurological deficits and reduces infarct volume in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yao, H., Liao, Z.-X., Wu, Q., et al. Antioxidative flavanone glycosides from the branches and leaves of Viscum coloratum. Chem. Pharm. Bull. (Tokyo) 54(1), 133-135 (2006).

    2. Hu, Q., Zhang, D.D., Wang, L., et al. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem. Toxicol. 50(6), 1927-1932 (2012).

    3. Jing, X., Ren, D., Wei, X., et al. Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. Toxicol. Appl. Pharmacol. 273(3), 672-679 (2013).