An SGLT2 inhibitor and active metabolite of dapagliflozin
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Parent Compound(s)
11574Dapagliflozin
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O-desethyl Dapagliflozin

Item No. 36022

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol
CAS Number
864070-37-1
Molecular Formula
C19H21ClO6
Formula Weight
380.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]([C@H]1O)[C@H](C(C=C2)=CC(CC(C=C3)=CC=C3O)=C2Cl)O[C@@H]([C@H]1O)CO
InChi Code
InChI=1S/C19H21ClO6/c20-14-6-3-11(8-12(14)7-10-1-4-13(22)5-2-10)19-18(25)17(24)16(23)15(9-21)26-19/h1-6,8,15-19,21-25H,7,9H2/t15-,16-,17+,18-,19+/m1/s1
InChi Key
ODQAIMBPQWETBE-FQBWVUSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $156

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    10 mg

    $279

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    25 mg

    $618

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    50 mg

    $1,082

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    O-desethyl Dapagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 9.4 nM) and active metabolite of dapagliflozin (Item No. 11574).1,2 It is selective for SGLT2 over SGLT1 (IC50 = 970 nM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, B., Feng, Y., Cheng, H., et al. C-aryl glucosides substituted at the 4'-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg. Med. Chem. Lett. 21(15), 4465-4470 (2011).

    2. Xu, G., Lv, B., Roberge, J.Y., et al. Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes. J. Med. Chem. 57(4), 1236-1251 (2014).