A synthetic peptide derivative of somatostatin
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TT-232 (trifluoroacetate salt)

Item No. 36045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-L-threoninamide cyclic (2→6)-disulfide, trifluoroacetate salt
Molecular Formula
C45H58N10O9S2 • XCF3COOH
Formula Weight
947.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 12 mg/mlEthanol: Slightly solublePBS (pH 7.2): 0.3 mg/ml
SMILES
O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC1=O)CCCCN)=O)C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](N)CC2=CC=CC=C2)=O)=O)CC3=CC=C(C=C3)O)N[C@@H]1CC4=CNC5=CC=CC=C54.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C45H58N10O9S2.C2HF3O2/c1-25(56)38(39(48)58)55-45(64)37-24-66-65-23-36(53-40(59)31(47)19-26-9-3-2-4-10-26)44(63)51-34(20-27-14-16-29(57)17-15-27)42(61)52-35(21-28-22-49-32-12-6-5-11-30(28)32)43(62)50-33(41(60)54-37)13-7-8-18-46;3-2(4,5)1(6)7/h2-6,9-12,14-17,22,25,31,33-38,49,56-57H,7-8,13,18-21,23-24,46-47H2,1H3,(H2,48,58)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,54,60)(H,55,64);(H,6,7)/t25-,31-,33+,34+,35-,36+,37+,38+;/m1./s1
InChi Key
DONBUNHQHAMXKX-YWCUHKGISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $160

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    10 mg

    $256

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    25 mg

    $559

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    50 mg

    $957

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    Cayman Chemical
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    Product Description

    TT-232 is a synthetic peptide derivative of somatostatin.1 It binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM). TT-232 (30 and 60 µg/ml) inhibits the proliferation of P388 murine and HL-60 human leukemia cells.2 In vivo, TT-232 (3-12 µg/animal per day) reduces tumor volume in an HL-60 mouse xenograft model. It inhibits intradermal neutrophil accumulation and ear edema induced by capsaicin (Item Nos. 92350 | 10010743) in rats.3 TT-232 (5-20 µg/kg, i.p.) inhibits mechano-nociceptive hyperalgesia in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simon, Á., Kéri, G., and Kardos, J. Comparison of the binding modes of TT-232 in somatostatin receptors type 1 and 4. Theochem. 816(1-3), 73-76 (2007).

    2. Tejeda, M., Gaal, D., Csuka, O., et al. Growth inhibitory effect of the somatostatin structural derivative (TT-232) on leukemia models. Anticancer Res. 25(1A), 325-330 (2005).

    3. Pintér, E., Helyes, Z., Németh, J., et al. Pharmacological characterisation of the somatostatin analogue TT-232: Effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. Naunyn Schmiedebergs Arch. Pharmacol. 366(2), 142-150 (2002).