An inhibitor of SARS-CoV and SARS-CoV-2 Mpro
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Pro-drug Form(s)
37026PF-07304814
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PF-00835231

Item No. 36047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-indole-2-carboxamide
CAS Number
870153-29-0
Molecular Formula
C24H32N4O6
Formula Weight
472.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
236, 292 nm
SMILES
OCC([C@H](C[C@H]1C(NCC1)=O)NC([C@H](CC(C)C)NC(C2=CC3=C(OC)C=CC=C3N2)=O)=O)=O
InChi Code
InChI=1S/C24H32N4O6/c1-13(2)9-18(23(32)27-17(20(30)12-29)10-14-7-8-25-22(14)31)28-24(33)19-11-15-16(26-19)5-4-6-21(15)34-3/h4-6,11,13-14,17-18,26,29H,7-10,12H2,1-3H3,(H,25,31)(H,27,32)(H,28,33)/t14-,17-,18-/m0/s1
InChi Key
QDIMHKWNHMVDJB-WBAXXEDZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    PF-00835231 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro; Kis = 4 and 0.27 nM, respectively).1 It reduces the infectivity of SARS-CoV and common cold human coronavirus 229E (HCoV-229E) in Vero cells (EC50s = 4.8 and 0.09 µM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffman, R.L., Kania, R.S., Brothers, M.A., et al. Discovery of ketone-based covalent inhibitors of coronavirus 3CL proteases for the potential therapeutic treatment of COVID-19. J. Med. Chem. 63(21), 12725-12747 (2020).