A muscarinic acetylcholine receptor antagonist
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Active Metabolite(s)
41013Propiverine N-oxide
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Propiverine (hydrochloride)

Item No. 36049

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-phenyl-α-propoxy-benzeneacetic acid, 1-methyl-4-piperidinyl ester, monohydrochloride
CAS Number
54556-98-8
Molecular Formula
C23H29NO3 • HCl
Formula Weight
403.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly solubleEthanol: Slightly soluble
SMILES
O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)OCCC)OC3CCN(CC3)C.Cl
InChi Code
InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H
InChi Key
KFUJMHHNLGCTIJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $44

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    50 mg

    $84

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    100 mg

    $131

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    250 mg

    $260

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    Product Description

    Propiverine is an antagonist of muscarinic acetylcholine receptors (mAChRs).1 It binds to M1 and M2 mAChRs in rat bladder and submaxillary gland, respectively (Kis = 0.3 and 0.19 µM, respectively), and inhibits carbachol-induced contraction of bladder strips isolated from patients with normal bladder activity and detrusor overactivity associated with benign prostatic hyperplasia (pA2s = 7.7 and 7.6, respectively).2 Formulations containing propiverine have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamada, S., Ito, Y., Taki, Y., et al. The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: Muscarinic receptor binding and pharmacokinetics. Drug Metab. Dispos. 38(8), 1314-1321 (2010).

    2. Yamanishi, T., Kaga, K., Fuse, M., et al. The role of muscarinic receptor subtypes on carbachol-induced contraction of normal human detrusor and overactive detrusor associated with benign prostatic hyperplasia. J. Pharmacol. Sci. 128(2), 65-70 (2015).