A pyridoindole antioxidant
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Stobadine

Item No. 36082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,4aR,5,9bS-hexahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
CAS Number
85202-17-1
Synonyms
  • Stobadin
Molecular Formula
C13H18N2
Formula Weight
202.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: >100 mM
SMILES
CC1=CC=C2N[C@@](CCN(C3)C)([H])[C@@]3([H])C2=C1
InChi Code
InChI=1S/C13H18N2/c1-9-3-4-12-10(7-9)11-8-15(2)6-5-13(11)14-12/h3-4,7,11,13-14H,5-6,8H2,1-2H3/t11-,13-/m1/s1
InChi Key
CYJQCYXRNNCURD-DGCLKSJQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $57

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    5 mg

    $266

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    10 mg

    $475

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    25 mg

    $834

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    Product Description

    Stobadine is a pyridoindole antioxidant.1 It scavenges hydroxyl, peroxyl, and alkoxyl radicals and quenches singlet oxygen in cell-free assays. Ex vivo, stobadine (2 mg/kg) reduces lipid peroxidation induced by hypoxia and reoxygenation in rat forebrain.2 It improves survival in a rat model of carotid artery ligation-induced cerebral ischemia. Stobadine (1 mg/kg, i.v.) increases myocardial blood flow and decreases infarct area in a dog model of myocardial infarction induced by acute occlusion of the left coronary artery.1 Dietary administration of stobadine (0.05% w/w) delays the development of cataracts and reduces eye lens protein oxidation and plasma levels of malondialdehyde (MDA) in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horáková, L., and Štolc, S. Antioxidant and pharmacodynamic effects of pyridoindole stobadine. Gen. Pharmacol. 30(5), 627-638 (1998).

    2. Štolc, S., Vlkolinský, R., and Pavlásek, J. Neuroprotection by the pyridoindole stobadine: A minireview. Brain Res. Bull. 42(5), 335-340 (1997).

    3. Kyselova, Z., Gajdosik, A., Gajdosikova, A., et al. Effect of the pyridoindole antioxidant stobadine on development of experimental diabetic cataract and on lens protein oxidation in rats: Comparison with vitamin E and BHT. Mol. Vis. 11, 56-65 (2005).