A non-steroidal mineralocorticoid receptor antagonist
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Finerenone

Item No. 36086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide
CAS Number
1050477-31-0
Synonyms
  • BAY 94-8862
Molecular Formula
C21H22N4O3
Formula Weight
378.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 3 mg/mlEthanol: insolPBS (pH 7.2): insol
λmax
255 nm
SMILES
CCOC1=C2[C@@H](C3=C(C=C(C=C3)C#N)OC)C(C(N)=O)=C(NC2=C(C=N1)C)C
InChi Code
InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m0/s1
InChi Key
BTBHLEZXCOBLCY-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $110

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    10 mg

    $209

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    25 mg

    $304

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    50 mg

    $550

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    Product Description

    Finerenone is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 18 nM).1 It is selective for the mineralocorticoid receptor over glucocorticoid, progesterone, and androgen receptors (IC50s = >10,000 nM for all), as well as L-type calcium channels (IC50 = >10,000 nM). Finerenone (3 mg/kg) reduces renal vasculopathy, fibrosis, and tubular degeneration, as well as cardiac fibrosis, in a rat model of hypertension-induced end-organ damage.2 It also increases exercise capacity and prevents diastolic dysfunction in ovariectomized mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolkhof, P., Jaisser, F., Kim, S.-Y., et al. Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: Comparison at bench and bedside. Handb. Exp. Pharmacol. 243, 271-305 (2017).

    2. Kolkhof, P., Hartmann, E., Freyberger, A., et al. Effects of finerenone combined with empagliflozin in a model of hypertension-induced end-organ damage. Am. J. Nephrol. 52(8), 642-652 (2021).

    3. Pieronne-Deperrois, M., Guéret, A., Djerada, Z., et al. Mineralocorticoid receptor blockade with finerenone improves heart function and exercise capacity in ovariectomized mice. ESC Heart Fail. 8(3), 1933-1943 (2021).