An internal standard for the quantification of LTB4
Related Products
Alternative(s)
320110Leukotriene B4-d4
Unlabeled Version(s)
20110Leukotriene B4
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Leukotriene B4-d5

Item No. 36097

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic-19,19,20,20,20-d5 acid
Synonyms
  • LTB4-d5
Molecular Formula
C20H27D5O4
Formula Weight
341.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
270 nm
SMILES
O[C@H](C/C=C\CCCC([2H])([2H])C([2H])([2H])[2H])/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
InChi Code
InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1/i1D3,2D2
InChi Key
VNYSSYRCGWBHLG-SUCHLTMXSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 µg

    $152

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    25 µg

    $343

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    50 µg

    $608

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    Product Description

    Leukotriene B4-d5 (LTB4-d5) is intended for use as an internal standard for the quantification of LTB4 (Item No. 20110) by GC- or LC-MS. LTB4 is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase (5-LO) pathway.1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10−10 M), LTB4 induces chemotaxis and chemokinesis in human polymorphonuclear leukocytes.4 At higher concentrations, (1.0 x 10−7 M), LTB4 leads to neutrophil aggregation and degranulation as well as superoxide anion production.4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem. Biophys. Res. Commun. 92(3), 954-961 (1980).

    2. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286(5770), 264-265 (1980).

    3. McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A4. Purification and characterization of a novel epoxide hydrolase from human erythrocytes. The Journal of Biological Chemisty 260(23), 12832-12837 (1985).

    4. Ford-Hutchinson, A.W. Leukotriene B4 in inflammation. Crit. Rev. Immunol. 10(1), 1-12 (1990).

    5. McMillan, R.M., and Foster, S.J. Leukotriene B4 and inflammatory disease. Agents Actions 24(1-2), 114-119 (1988).