A flavonoid with antioxidant and anticancer activities
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3'-Hydroxygenkwanin

Item No. 36150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
CAS Number
20243-59-8
Synonyms
  • HGK
  • Luteolin 7-methyl ether
  • 7-O-Methylluteolin
Molecular Formula
C16H12O6
Formula Weight
300.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 2 mg/ml
λmax
255, 352 nm
SMILES
O=C1C=C(C2=CC(O)=C(O)C=C2)OC3=CC(OC)=CC(O)=C13
InChi Code
InChI=1S/C16H12O6/c1-21-9-5-12(19)16-13(20)7-14(22-15(16)6-9)8-2-3-10(17)11(18)4-8/h2-7,17-19H,1H3
InChi Key
RRRSSAVLTCVNIQ-UHFFFAOYSA-N
Origin
Plant/Daphne genkwa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $44

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    10 mg

    $84

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    25 mg

    $196

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    50 mg

    $369

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    Cayman Chemical
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    Product Description

    3’-Hydroxygenkwanin is a flavonoid that has been found in B. balsamifera and has antioxidant and anticancer activities.1,2 It scavenges superoxide anions in a cell-free assay when used at a concentration of 100 µM.1 3’-Hydroxygenkwanin (25 and 50 µM) decreases the levels of EGFR and phosphorylated EGFR in, and reduces viability of, PC-9 and H1975 non-small cell lung cancer (NSCLC) cells.2 It also decreases intratumoral levels of EGFR and phosphorylated EGFR and reduces tumor growth in an H1975 mouse xenograft model when administered at a dose of 1 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fazilatun, N., Nornisah, M., and Zhari, I. Superoxide radical scavenging properties of extracts and flavonoids isolated from the leaves of Blumea balsamifera. Pharm. Biol. 42(6), 404–408 (2004).

    2. Leu, Y.-L., Wang, T.-H., Wu, C.-C., et al. Hydroxygenkwanin suppresses non-small cell lung cancer progression by enhancing EGFR degradation. Molecules 25(4), 941 (2020).