A flavonoid with diverse biological activities
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Hispidulin

Item No. 26383

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
CAS Number
1447-88-7
Synonyms
  • Dinatin
  • 6-Methoxyapigenin
  • NSC 122415
Molecular Formula
C16H12O6
Formula Weight
300.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
218, 275, 336 nm
SMILES
OC1=C(OC)C(O)=C(C(C=C(C2=CC=C(O)C=C2)O3)=O)C3=C1
InChi Code
InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3
InChi Key
IHFBPDAQLQOCBX-UHFFFAOYSA-N
Origin
Plant/Salvia plebeia R. Br.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

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    25 mg

    $336

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    Product Description

    Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.1,2,3,4,5 It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), and ADP (IC50s = 20, 4, and 13 μM, respectively).1 Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).2 In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.3 Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Item No. 23996) in aged rats.4 It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bourdillat, B., Delautier, D., Labat, C., et al. Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur. J. Pharmacol. 147(1), 1-6 (1988).

    2. Nepal, M., Choi, H.J., Choi, B.-Y., et al. Hispidulin attenuates bone resorption and osteoclastogenesis via the RANKL-induced NF-κB and NFATc1 pathways. Eur. J. Pharmacol. 715(1-3), 96-104 (2013).

    3. Gao, H., Gao, M.-Q., Peng, J.-J., et al. Hispidulin mediates apoptosis in human renal cell carcinoma by inducing ceramide accumulation. Acta Pharmacol. Sin. 38(12), 1618-1631 (2017).

    4. Huang, L., Huang, K., and Ning, H. Autophagy induction by hispidulin provides protection against sevoflurane-induced neuronal apoptosis in aged rats. Biomed. Pharmacother. 98, 460-468 (2018).

    5. An, P., Wu, T., Yu, H., et al. Hispidulin protects against focal cerebral ischemia reperfusion injury in rats. J. Mol. Neurosci. 65(2), 203-212 (2018).