A diterpene alkaloid with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Bullatine B

Item No. 36170

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-(1α,6α,14α,16β)-aconitane-1,8,14-triol
CAS Number
466-26-2
Synonyms
  • Neoline
Molecular Formula
C24H39NO6
Formula Weight
437.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O[C@@H](CC1)C(C(N2CC)C3[C@@H]4OC)([C@@](C[C@H]5[C@]6([H])O)([H])[C@H]6[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]1(C2)COC
InChi Code
InChI=1S/C24H39NO6/c1-5-25-10-22(11-29-2)7-6-15(26)24-13-8-12-14(30-3)9-23(28,16(13)18(12)27)17(21(24)25)19(31-4)20(22)24/h12-21,26-28H,5-11H2,1-4H3/t12-,13-,14+,15+,16-,17?,18+,19+,20-,21?,22+,23-,24?/m1/s1
InChi Key
XRARAKHBJHWUHW-XPGJPNGISA-N
Origin
Plant/Aconitum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $82

    Add

    5 mg

    $283

    Add

    10 mg

    $443

    Add

    25 mg

    $803

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Bullatine B is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.1,2 It inhibits voltage-gated sodium channel 1.7 (Nav1.7) in HEK293 cells expressing the human channel (IC50 = 25.8 nM) and scavenges DPPH (Item No. 14805) radicals by 65.3% at 1 mM. Bullatine B (10 mg/kg) increases the mechanical pain threshold in the von Frey test in streptozotocin-induced diabetic, but not non-diabetic, mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakatani, Y., Negoro, K., Yamauchi, M., et al. Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. J. Ethnopharmacol. 259, 112963 (2020).

    2. Begum, S., Ali, A., Ahman, W., et al. Pharmacologically active C-19 diterpenoid alkaloids from the aerial parts of Aconitum laeve royle. Rec. Nat. Prod. 8(2), 83-92 (2014).