For immunochemical detection of citrullinated IL-6
Related Products
Measurement and Detection Tool(s)
30173Citrullinated Interleukin-6 (human, recombinant)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Citrullinated Interleukin-6 Polyclonal Antibody

Item No. 36178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • B Cell Stimulatory Factor 2
  • BSF-2
  • CDF
  • CTL Differentiation Factor
  • HGF
  • Hybridoma Growth Factor
  • IFN-β2
  • IL-6
  • Interferon-β2
Immunogen
Synthetic citrullinated peptide corresponding to an internal region of human IL-6
MW
~24 kDa
Formulation (Request formulation change)
1 ml of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
ELISA, WB
Cross Reactivity
(+) Citrullinated IL-6
Species Reactivity
(+) Human(-) Others not tested
UniProt Accession №
P05231
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 ml

    $531

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Interleukin-6 (IL-6) is a cytokine with roles in both the initiation and resolution of inflammatory responses.1,2 IL-6 is produced in response to an inflammatory event, induces recruitment of neutrophils to the site of inflammation, and signals through the membrane-bound IL-6 receptor (IL-6R) to upregulate the synthesis of acute phase proteins, lipolysis in the liver, and induced differentiation of T and B cells. Following initiation of this classical signaling pathway, a soluble form of IL-6R (sIL-6R) is released from neutrophils to promote recruitment of monocytes and macrophages, induction of fever via IL-6 action in the hypothalamus, and production of anti-inflammatory M2 macrophages to initiate tissue repair. Production of IL-6 is dysregulated in various chronic inflammatory diseases, including rheumatoid arthritis, Castleman disease, polymyalgia rheumatica, and giant cell arteritis.3 It also induces tumor growth and metastasis via activation of JAK/STAT signaling.4 Recombinant human IL-6 can be citrullinated at arginine residues by protein arginine deiminase 4 (PAD4) in vitro.5 Citrullinated IL-6 and anti-citrullinated peptide antibodies (ACPAs) reactive with citrullinated IL-6 have been found in synovial fluid and sera, respectively, from patients with rheumatoid arthritis. Cayman's Citrullinated Interleukin-6 Polyclonal Antibody can be used for ELISA and Western blot (WB) applications. The antibody recognizes citrullinated IL-6 at ~24 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Del Giudice, M., and Gangestad, S.W. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav. Immun. 70, 61-75 (2018).

    2. Rose-John, S. Interleukin-6 family cytokines. Cold Spring Harb. Perspect. Biol. 10(2), a028415 (2018).

    3. Schett, G. Physiological effects of modulating the interleukin-6 axis. Rheumatology (Oxford) 57(suppl_2), ii43-ii50 (2018).

    4. Lacina, L., Brábek, J., Král, V., et al. Interleukin-6: A molecule with complex biological impact in cancer. Histol. Histopathol. 34(2), 125-136 (2019).

    5. Lu, C., Ohara, R., Campbell, P., et al. Citrullination of interleukin 6 augments its pro-inflammatory capacity and signaling potency through interleukin-6 receptor in rheumatoid arthritis [abstract]. Arthritis Rheumatol. 71 (suppl 10), (2019).