A tetrapeptide regulator of hematopoiesis
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Goralatide (acetate)

Item No. 36207

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-seryl-D-α-aspartyl-L-lysyl-L-proline, acetate
Synonyms
  • N-Acetyl-Ser-Asp-Lys-Pro
  • AcSDKP
Molecular Formula
C20H33N5O9 • XC2H4O2
Formula Weight
487.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
CC(N[C@@H](CO)C(N[C@H](CC(O)=O)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(O)=O)=O)=O)=O)=O.CC(O)=O
InChi Code
InChI=1S/C20H33N5O9.C2H4O2/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34;1-2(3)4/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34);1H3,(H,3,4)/t12-,13+,14-,15-;/m0./s1
InChi Key
IYSLFKMYLHUWSA-UOIZBMALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

    $102

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    10 mg

    $186

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    25 mg

    $388

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    Cayman Chemical
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    Product Description

    Goralatide is a tetrapeptide regulator of hematopoiesis.1 It decreases the proportion of mouse high proliferative potential colony forming cells (HPP-CFCs) in S phase when cultured using regenerating femoral marrow conditioned medium at a concentration of 1 ng/ml. Goralatide (4 µg/kg twice per day) reduces decreases in the number of HPP-CFCs, burst-forming unit erythroid (BFU-E) cells, and colony forming unit granulocyte-macrophages (CFU-GMs) induced by 5-fluorouracil (5-FU; Item No. 14416) in mice.2 It also reduces mortality induced by doxorubicin (Item No. 15007) in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Robinson, S., Lenfant, M., Wdzieczak-Bakala, J., et al. The molecular specificity of action of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (AcSDKP) in the control of hematopoietic stem cell proliferation. Stem Cells 11(5), 422-427 (1993).

    2. Aidoudi, S., Guigon, M., Lebeurier, I., et al. In vivo effect of platelet factor 4 (PF4) and tetrapeptide AcSDKP on haemopoiesis of mice treated with 5-fluorouracil. Br. J. Haematol. 94(3), 443-448 (1996).

    3. Massé, A., Ramirez, L.H., Bindoula, G., et al. The tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Goralatide) protects from doxorubicin-induced toxicity: Improvement in mice survival and protection of bone marrow stem cells and progenitors. Blood 91(2), 441-449 (1998).