An anticoagulant rodenticide and a vitamin K antagonist
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Difethialone

Item No. 36225

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-(4′-bromo[1,1′-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzothiopyran-2-one
CAS Number
104653-34-1
Synonyms
  • LM-2219
Molecular Formula
C31H23BrO2S
Formula Weight
539.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly solubleMethanol: Slightly soluble: 0.1-1 mg/mL
SMILES
O=C1SC2=C(C(O)=C1C3C4=CC=CC=C4CC(C3)C5=CC=C(C6=CC=C(C=C6)Br)C=C5)C=CC=C2
InChi Code
InChI=1S/C31H23BrO2S/c32-24-15-13-20(14-16-24)19-9-11-21(12-10-19)23-17-22-5-1-2-6-25(22)27(18-23)29-30(33)26-7-3-4-8-28(26)35-31(29)34/h1-16,23,27,33H,17-18H2
InChi Key
JHELOZJAKXYVBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $439

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    Product Description

    Difethialone is an anticoagulant rodenticide and a vitamin K antagonist.1 It binds to vitamin K epoxide reductase (VKOR; Kis = 0.04 and 0.05 µM for the wild-type and VKORY139F enzyme, respectively). Difethialone is toxic to mice (LD50 = 1.29 mg/kg).2 Formulations containing difethialone have been used in the control of rodent pest populations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hodroge, A., Longin-Sauvageon, C., Fourel, I., et al. Biochemical characterization of spontaneous mutants of rat VKORC1 involved in the resistance to antivitamin K anticoagulants. Arch. Biochem. Biophys. 515(1-2), 14-20 (2011).

    2. Vandenbroucke, V., Bousquet-Melou, A., De Backer, P., et al. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J. Vet. Pharmacol. Ther. 31(5), 437-445 (2008).