A DNA alkylating agent
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1-Ethyl-1-nitrosourea (hydrate)

Item No. 36264

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-ethyl-N-nitroso-urea, hydrate
Synonyms
  • ENU
  • Ethylnitrosourea
  • N-Ethyl-N-nitrosourea
  • N-Nitroso-N-ethylurea
Molecular Formula
C3H7N3O2 • XH2O
Formula Weight
117.1
Purity
≥95%
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
240 nm
SMILES
O=NN(CC)C(N)=O
InChi Code
InChI=1S/C3H7N3O2/c1-2-6(5-8)3(4)7/h2H2,1H3,(H2,4,7)
InChi Key
FUSGACRLAFQQRL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

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    10 g

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    Cayman Chemical
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    Product Description

    1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.1 It increases the concentrations of O6-ethylguanine, N7-ethylguanine, N7-ethyladenine, and N3-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenic in vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goth, R., and Rajewsky, M.F. Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosourea. Proc. Natl. Acad. Sci. USA 71(3), 639-643 (1974).

    2. Druckrey, H., Ivanković, S., and Preussmann, R. Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature 210(5043), 1378-1379 (1966).