A vitamin C derivative
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Ascorbyl Tetraisopalmitate

Item No. 36275

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,5,6-tetrakis(2-hexyldecanoate) L-ascorbic acid
CAS Number
183476-82-6
Synonyms
  • tetra-isopalmitoyl Ascorbic Acid
  • IPAA
  • Tetrahexyldecyl Ascorbate
  • VC-IP
  • Vitamin C-isopalmityl tetraester
Molecular Formula
C70H128O10
Formula Weight
1129.8
Purity
≥95%
Formulation (Request formulation change)
A neat liquid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: insolEthanol: 10 mg/mlPBS (pH 7.2): insol
λmax
223 nm
SMILES
CCCCCCC(CCCCCCCC)C(OC[C@H](OC(C(CCCCCCCC)CCCCCC)=O)[C@@]1([H])OC(C(OC(C(CCCCCCCC)CCCCCC)=O)=C1OC(C(CCCCCC)CCCCCCCC)=O)=O)=O
InChi Code
InChI=1S/C70H128O10/c1-9-17-25-33-37-45-50-58(49-41-29-21-13-5)66(71)76-57-62(77-67(72)59(51-42-30-22-14-6)54-46-38-34-26-18-10-2)63-64(79-68(73)60(52-43-31-23-15-7)55-47-39-35-27-19-11-3)65(70(75)78-63)80-69(74)61(53-44-32-24-16-8)56-48-40-36-28-20-12-4/h58-63H,9-57H2,1-8H3/t58?,59?,60?,61?,62-,63+/m0/s1
InChi Key
OEWBEINAQKIQLZ-CMRBMDBWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 g

    $73

    Add

    10 g

    $137

    Add

    25 g

    $324

    Add

    50 g

    $610

    Add
    Product Description

    Ascorbyl tetraisopalmitate is a lipophilic derivative of vitamin C (L-ascorbic acid; Item No. 14656).1,2 It protects against UVB-, hydrogen peroxide-, or tert-butyl hydroperoxide-induced decreases in cell viability in HaCaT keratinocytes when used at a concentration of 100 µM.1 Ascorbyl tetraisopalmitate (20 µM) decreases IL-1α and prostaglandin E2 (PGE2; Item No. 14010) production in unstimulated and UVB-stimulated HaCaT keratinocytes. Topical application of ascorbyl tetraisopalmitate (1%) increases viable epidermis thickness, stratum corneum water content, and skin smoothness and decreases skin roughness in hairless mice.2 Formulations containing ascorbyl tetraisopalmitate have been used in cosmetic products as skin-lightening agents.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ochiai, Y., Kaburagi, S., Obayashi, K., et al. A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative properties. J. Dermatol. Sci. 44(1), 37-44 (2006).

    2. Maia Campos, P.M.B.G., Gianeti, M.D., Camargo, F.B., Jr., et al. Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacy. Eur. J. Pharm. Biopharm. 82(3), 580-586 (2012).