An excitatory amino acid antagonist
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γ-D-Glutamylglycine (trifluoroacetate salt)

Item No. 36278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-D-γ-glutamyl-glycine, trifluoroacetate salt
CAS Number
71822-19-0
Synonyms
  • γ-DGG
Molecular Formula
C7H12N2O5 • CF3COOH
Formula Weight
318.2
Purity
≥95%
Formulation (Request formulation change)
A semi-solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC(CNC(CC[C@@H](N)C(O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C7H12N2O5.C2HF3O2/c8-4(7(13)14)1-2-5(10)9-3-6(11)12;3-2(4,5)1(6)7/h4H,1-3,8H2,(H,9,10)(H,11,12)(H,13,14);(H,6,7)/t4-;/m1./s1
InChi Key
UBOUYYUIWKVKPI-PGMHMLKASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $82

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    50 mg

    $154

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    100 mg

    $291

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    250 mg

    $685

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    Product Description

    γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA (Item No. 14581), quisqualate, kainate, and glutamate.1 It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively).2 γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crunelli, S., Forda, S., and Kelly, J.S. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus. J. Physiol. 341, 627-640 (1983).

    2. Raigorodsky, G., and Urca, G. Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartate. Eur. J. Pharmacol. 182(1), 37-47 (1990).

    3. Croucher, M.J., Collins, J.F., and Meldrum, B.S. Anticonvulsant action of excitatory amino acid antagonists. Science 216(4548), 899-901 (1982).