An internal standard for the quantification of (±)-ibuprofen
Related Products
Alternative(s)
18255(±)-Ibuprofen-d3
Unlabeled Version(s)
70280(±)-Ibuprofen
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(±)-Ibuprofen-d3 (sodium salt)

Item No. 36332

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid-d3, monosodium salt
CAS Number
1219805-09-0
Synonyms
  • DL-Ibuprofen-d3
Molecular Formula
C13H14D3O2 • Na
Formula Weight
231.3
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
[O-]C(C(C1=CC=C(C=C1)CC(C)C)C([2H])([2H])[2H])=O.[Na+]
InChi Code
InChI=1S/C13H18O2.Na/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;/h4-7,9-10H,8H2,1-3H3,(H,14,15);/q;+1/p-1/i3D3;
InChi Key
PTTPUWGBPLLBKW-FJCVKDQNSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $119

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    10 mg

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    25 mg

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    50 mg

    $939

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    Product Description

    (±)-Ibuprofen-d3 is intended for use as an internal standard for the quantification of (±)-ibuprofen (Item No. 70280) by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).1 In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg).2 It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, J.L., Wimsatt, J., Buckel, S.D., et al. Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons. Arch. Biochem. Biophys. 324(1), 26-34 (1995).

    2. Seguin, L., Le Marouille-Girardon, S., and Millan, M.J. Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: A comparison to other classes of antinociceptive agent. Pain 61(2), 325-343 (1995).