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L-Tyrosine is a conditionally essential amino acid.1 It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2 L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3 Plasma, skeletal muscle, and erythrocyte levels of L-tyrosine are decreased in patients with chronic kidney disease.1
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1. Phenylalanine and tyrosine metabolism in chronic kidney failure. J. Nutr. 137(6 Suppl 1), 1586S-1590S (2007).
2. Tyrosine supplementation for phenylketonuria. Cochrane DB Syst. Rev. 6, CD001507 (2013).
3. Towards defining receptors for L-