An internal standard for the quantification of 7-methylguanosine
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Unlabeled Version(s)
159887-Methylguanosine
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7-Methylguanosine-d3

Item No. 36336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(methyl-d3)guanosine
Synonyms
  • m7G-d3
Molecular Formula
C11H12D3N5O5
Formula Weight
300.3
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 10 mg/mlDMSO: 10 mg/ml
SMILES
NC1=NC([O-])=C2[N+](C([2H])([2H])[2H])=CN([C@@]3([H])[C@H](O)[C@H](O)[C@@H](CO)O3)C2=N1
InChi Code
InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/t4-,6-,7-,10-/m1/s1/i1D3
InChi Key
OGHAROSJZRTIOK-IKRHYSCUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $37

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    1 mg

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    5 mg

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    Product Description

    7-Methylguanosine-d3 is intended for use as an internal standard for the quantification of 7-methylguanosine (Item No. 15988) by GC- or LC-MS. 7-Methylguanosine is a methylated form of the purine nucleoside guanosine (Item No. 27702). It is an RNA modification that is present in the 5’-terminal cap of mRNA, where it promotes translation, as well as in tRNA, where it stabilizes the tRNA structure.1,2 7-Methylguanosine has been used as a substrate to measure the activity of purine nucleoside phosphorylase (PNP).3 Urinary 7-methylguanosine levels are decreased in patients with prostate cancer.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández-Peralbo, M.A., Gómez-Gómez, E., Calderón-Santiago, M., et al. Prostate cancer patients-negative biopsy controls discrimination by untargeted metabolomics analysis of urine by LC-QTOF: Upstream information on other omics. Sci. Rep. 6, 38243 (2016).

    2. Tomikawa, C. 7-Methylguanosine modifications in transfer RNA (tRNA). Int. J. Mol. Sci. 19(12), 4080 (2018).

    3. Stachelska-Wierzchowska, A., and Wierzchowski, J. Non-typical nucleoside analogs as fluorescent and fluorogenic indicators of purine-nucleoside phosphorylase activity in biological samples. Anal. Chim. Acta 1139, 119-128 (2020).