An internal standard for the quantification of phenformin
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Phenformin-d5 (hydrochloride)

Item No. 36341

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(phenyl-2,3,4,5,6-d5)ethyl]-imidodicarbonimidic diamide, monohydrochloride
Molecular Formula
C10H10D5N5 • HCl
Formula Weight
246.8
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5mg/ml
SMILES
N=C(NC(NCCC1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])=N)N.Cl
InChi Code
InChI=1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H/i1D,2D,3D,4D,5D;
InChi Key
YSUCWSWKRIOILX-GWVWGMRQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $87

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    5 mg

    $387

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    10 mg

    $676

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Phenformin-d5 is intended for use as an internal standard for the quantification of phenformin by GC- or LC-MS. Phenformin is an antihyperglycemic biguanide.1 It reduces blood glucose levels in a mouse model of diabetes induced by alloxan (Item No. 9002196) when administered at a dose of 100 mg/kg. Phenformin (250 mg/kg) induces lactic acidosis in diabetic dogs.2 It also inhibits tumor growth of MCF-7 and MDA-MB-231 breast cancer mouse xenograft models when administered at a dose of 300 mg/kg.3 Formulations containing phenformin were previously used in the treatment of diabetes mellitus.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W.-L., Wu, J.-L., Ren, B.-R., et al. Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae. Am. J. Chin. Med. 35(4), 705-711 (2007).

    2. Arieff, A.I., Park, R., Leach, W.J., et al. Pathophysiology of experimental lactic acidosis in dogs. Am. J. Physiol. 239(2), F135-F142 (1980).

    3. Appleyard, M.V.C.L., Murray, K.E., Coates, P.J., et al. Phenformin as prophylaxis and therapy in breast cancer xenografts. Br. J. Cancer 106(6), 1117-1122 (2012).