An anthraquinone glycoside with diverse biological activities
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Isomer(s)
36087Frangulin A
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Pulmatin

Item No. 36343

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(β-D-glucopyranosyloxy)-1-hydroxy-3-methyl-9,10-anthracenedione
CAS Number
13241-28-6
Synonyms
  • Chrysophanol 8-O-glucoside
  • Chrysophanol 8-O-β-D-glucopyranoside
Molecular Formula
C21H20O9
Formula Weight
416.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(C1=CC(C)=CC(O)=C12)C3=CC=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3C2=O
InChi Code
InChI=1S/C21H20O9/c1-8-5-10-14(11(23)6-8)18(26)15-9(16(10)24)3-2-4-12(15)29-21-20(28)19(27)17(25)13(7-22)30-21/h2-6,13,17,19-23,25,27-28H,7H2,1H3/t13-,17-,19+,20-,21-/m1/s1
InChi Key
WMMOMSNMMDMSRB-JNHRPPPUSA-N
Origin
Plant/Rheum emodi
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $98

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    5 mg

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    10 mg

    $879

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    Cayman Chemical
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    Product Description

    Pulmatin is an anthraquinone glycoside that has been found in R. emodi and has diverse biological activities.1,2,3 It inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 18.34 µM) and yeast and rat intestinal α-glucosidase when used at a concentration of 50 µg/ml.1,2 Pulmatin (25 µM) increases insulin-induced glucose transport by 255% in L6 myotubes.1 It lowers plasma levels of total cholesterol, phospholipids, LDL, VLDL, and triglycerides in a rat model of Triton WR-1339-induced dyslipidemia when administered at a dose of 100 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, M.S., and Sohn, C.B. Anti-diabetic properties of chrysophanol and its glucoside from rhubarb rhizome. Biol. Pharm. Bull. 31(11), 2154-2157 (2008).

    2. Babu, K.S., Tiwari, A.K., Srinivas, P.V., et al. Yeast and mammalian a-glucosidase inhibitory constituents from Himalayan rhubarb Rheum emodi Wall.ex Meisson. Bioorg. Med. Chem. Lett. 14(14), 3841-3845 (2004).

    3. Mishra, S.K., Tiwari, S., Shrivastava, A., et al. Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats. J. Nat. Med. 68(2), 363-371 (2014).