A bacterial metabolite
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3-(4-Hydroxyphenyl)lactic Acid

Item No. 36367

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α,4-dihydroxy-benzenepropanoic acid
CAS Number
306-23-0
Synonyms
  • HPLA
  • (±)-3-(4-Hydroxyphenyl)lactic Acid
  • β-(4-Hydroxyphenyl)-DL-Lactic Acid
  • DL-p-Hydroxyphenyllactic Acid
Molecular Formula
C9H10O4
Formula Weight
182.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
226 nm
SMILES
O=C(C(CC1=CC=C(C=C1)O)O)O
InChi Code
InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)
InChi Key
JVGVDSSUAVXRDY-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    500 mg

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    Product Description

    3-(4-Hydroxyphenyl)lactic acid (HPLA) is a bacterial metabolite produced by L. murinus in the gut microbiome.1 Oral administration of HPLA with DL-3-phenylacetic acid (PLA), 2-hydroxyisocaproic acid (HICA), 2-hydroxy-3-methylbutyric acid (HMBA), and 1-indole-lactic acid (ILA) increases intestinal and white adipose tissue lipid absorption and decreases fatty acid oxidation in a mouse model of refeeding-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zarrinpar, A. A high-protein diet prevents weight regain. Nat. Metab. 4(12), 1616-1617 (2022).