A polyphenol with diverse biological activities
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Dihydrocaffeic Acid

Item No. 28390

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydroxy-benzenepropanoic acid
CAS Number
1078-61-1
Synonyms
  • 3,4-Dihydroxyhydrocinnamic Acid
Molecular Formula
C9H10O4
Formula Weight
182.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mLDMSO: 25 mg/mLEthanol: 10 mg/mLPBS (pH 7.2): 2 mg/ml
λmax
225, 284 nm
SMILES
OC1=C(O)C=CC(CCC(O)=O)=C1
InChi Code
InChI=1S/C9H10O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1,3,5,10-11H,2,4H2,(H,12,13)
InChi Key
DZAUWHJDUNRCTF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 g

    $53

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    10 g

    $94

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    25 g

    $180

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    50 g

    $332

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    Product Description

    Dihydrocaffeic acid is a polyphenol that has diverse biological activities, including antioxidant, neuroprotective, and enzyme inhibitory properties.1,2 Dihydrocaffeic acid scavenges ABTS (Item No. 27317; IC50 = 81.86 μg/ml) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805; IC50 = 192.86 μg/ml) radicals and increases the survival of RGC-5 mouse retinal ganglion cells under hypoxic conditions and in the presence of S-nitroso-N-acetyl-D,L-penicillamine (SNAP; Item No. 82250) in a concentration-dependent manner.1 It also decreases endothelial nitric oxide synthase (eNOS) activity in EA.hy926 human endothelial cells in a concentration-dependent manner.3 In vivo, dihydrocaffeic acid (30 mg/kg) decreases infarct size in a rat model of transient ischemia induced by middle cerebral artery occlusion (MCAO).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jang, H., Choi, Y., Ahn, H.R., et al. Effects of phenolic acid metabolites formed after chlorogenic acid consumption on retinal degeneration in vivo. Mol. Nutr. Food Res. 59(10), 1918-1929 (2015).

    2. Lee, K., Lee, B.J., and Bu, Y. Protective effects of dihydrocaffeic acid, a coffee component metabolite, on a focal cerebral ischemia rat model. Molecules 20(7), 11930-11940 (2015).

    3. Huang, J., De Paulis, T., and May, J.M. Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells. J. Nutr. Biochem. 15(12), 722-729 (2004).