An antagonist of mGluR1 and mGluR2
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Isomer(s)
363894-Hydroxyphenylpropionylglycine
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E4CPG

Item No. 36667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-amino-4-carboxy-α-ethyl-benzeneacetic acid
CAS Number
170846-89-6
Synonyms
  • (R,S)-α-Ethyl-4-carboxyphenylglycine
Molecular Formula
C11H13NO4
Formula Weight
223.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: insolEthanol: insolPBS (pH 7.2): 100 µg/ml
λmax
233 nm
SMILES
O=C(C1=CC=C(C(C(O)=O)(CC)N)C=C1)O
InChi Code
InChI=1S/C11H13NO4/c1-2-11(12,10(15)16)8-5-3-7(4-6-8)9(13)14/h3-6H,2,12H2,1H3,(H,13,14)(H,15,16)
InChi Key
AIEFWRHRHFRLFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $70

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    10 mg

    $124

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    25 mg

    $272

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    50 mg

    $477

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    Product Description

    E4CPG is an antagonist of metabotropic glutamate receptor 1 (mGluR1) and mGluR2.1 It is selective for mGluR1 and mGluR2 over mGluR6 at 1 mM. E4CPG (1 mM) inhibits L-glutamate-induced increases in inositol phosphate (InsP) levels in CHO cells expressing mGluR1 and prevents forskolin-induced decreases in cAMP levels in CHO cells expressing mGluR2. In vivo, intraplantar administration of E4CPG (1-10 nmol/paw) reduces glutamate-induced paw licking in a mouse model of nociceptive pain.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sekiyama, N., Hayashi, Y., Nakanishi, S., et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 117(7), 1493-1503 (1996).

    2. Beirith, A., Santos, A.R.S., and Calixto, J.B. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res. 924(2), 219-228 (2002).