A sterol lipid
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Anecortave Acetate

Item No. 36441

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-(acetyloxy)-17-hydroxy-pregna-4,9(11)-diene-3,20-dione
CAS Number
7753-60-8
Synonyms
  • AL 3789
  • NSC 15475
  • NSC 24345
Molecular Formula
C23H30O5
Formula Weight
386.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/ml
SMILES
C[C@@]12[C@](CC[C@]2(O)C(COC(C)=O)=O)([H])[C@@]3([H])C([C@@]4(C(CC3)=CC(CC4)=O)C)=CC1
InChi Code
InChI=1S/C23H30O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h7,12,17,19,27H,4-6,8-11,13H2,1-3H3/t17-,19+,21+,22+,23+/m1/s1
InChi Key
YUWPMEXLKGOSBF-GACAOOTBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    25 mg

    $87

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    50 mg

    $105

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    100 mg

    $157

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    Product Description

    Anecortave acetate is a sterol lipid.1 It inhibits VEGF-induced increases in vascular generation, number, and length in isolated rat retinas when used at a concentration of 1 µM. Sub-tenon administration of anecortave acetate (7.5% w/v) prevents and reduces increases in intraocular pressure induced by prednisolone (Item No. 20866) in sheep.2 Subconjunctival administration of anecortave acetate (15% w/v), in combination with 2-deoxyglucose, decreases tumor growth in a Tg(TagRb)1Plm mouse model of retinoblastoma.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Unoki, N., Murakami, T., Ogino, K., et al. Time-lapse imaging of retinal angiogenesis reveals decreased development and progression of neovascular sprouting by anecortave desacetate. Invest. Ophthalmol. Vis. Sci. 51(5), 2347-2355 (2010).

    2. Candia, O.A., Gerometta, R., Millar, J.C., et al. Suppression of corticosteroid-induced ocular hypertension in sheep by anecortave. Arch. Ophthalmol. 128(3), 338-343 (2010).

    3. Houston, S.K., Pina, Y., Murray, T.G., et al. Novel retinoblastoma treatment avoids chemotherapy: The effect of optimally timed combination therapy with angiogenic and glycolytic inhibitors on LHBETA TAG retinoblastoma tumors. Clin. Ophthalmol. 5, 129-137 (2011).