An internal standard for the quantification of choline
Related Products
Unlabeled Version(s)
43985Choline (acetate) 31178Choline (chloride)
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Choline-d9 (chloride)

Item No. 36454

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N,N,N-tri(methyl-d3)-ethanaminium, monochloride
CAS Number
61037-86-3
Molecular Formula
C5H5D9NO • Cl
Formula Weight
148.7
Purity
≥99% deuterated forms (d1-d9)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleEthanol: 2 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
[2H]C([2H])([2H])[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])CCO.[Cl-]
InChi Code
InChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1/i1D3,2D3,3D3;
InChi Key
SGMZJAMFUVOLNK-KYRNGWDOSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $213

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    1 g

    $277

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    Product Description

    Choline-d9 is intended for use as an internal standard for the quantification of choline (Item No. 31178) by GC- or LC-MS. Choline is an essential nutrient with roles in liver, neurological, hematological, and skeletal muscle homeostasis.1,2,3,4 It is a precursor in the biosynthesis of membrane phospholipids, such as phosphatidylcholine, which facilitate cell signaling and transport across the membrane, and a precursor to the neurotransmitter acetylcholine. Choline is required for hepatic lipid transport.1 Perinatal administration of choline (18.8 mg/kg) improves prenatal alcohol exposure-induced cognitive deficits in rats.2 Choline (13 mg/animal per day) improves motor coordination and behavioral deficits in a mouse model of Rett syndrome, as well as improves deficits in recognition memory induced by early-life iron deficiency in rats when administered in the drinking water at a concentration of 5 ppm.3 Deficiencies in choline intake are positively correlated with muscle wasting, and dietary administration of choline (1,000 mg/kg) increases leg and breast muscle protein content in broiler chickens.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanders, L.M., and Zeisel, S.H. Choline: Dietary requirements and role in brain development. Nutr. Today 42(4), 181-186 (2007).

    2. Thomas, J.D., Garrison, M., and O'Neill, T.M. Perinatal choline supplementation attenuates behavioral alterations associated with neonatal alcohol exposure in rats. Neurotoxicol. Teratol. 26(1), 35-45 (2004).

    3. Derbyshire, E., and Obeid, R. Choline, neurological development and brain function: A systematic review focusing on the first 1000 days. Nutrients 12(6), 1731 (2020).

    4. Moretti, A., Paoletta, M., Liguori, S., et al. Choline: An essential nutrient for skeletal muscle. Nutrients 12(7), E2144 (2020).