An inhibitor of ATM kinase
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AZD 1390

Item No. 36498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-2H-imidazo[4,5-c]quinolin-2-one
CAS Number
2089288-03-7
Molecular Formula
C27H32FN5O2
Formula Weight
477.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
249, 269 nm
SMILES
O=C1N(C)C2=C(N1C(C)C)C3=CC(C4=CN=C(OCCCN5CCCCC5)C=C4)=C(F)C=C3N=C2
InChi Code
InChI=1S/C27H32FN5O2/c1-18(2)33-26-21-14-20(22(28)15-23(21)29-17-24(26)31(3)27(33)34)19-8-9-25(30-16-19)35-13-7-12-32-10-5-4-6-11-32/h8-9,14-18H,4-7,10-13H2,1-3H3
InChi Key
VQSZIPCGAGVRRP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

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    10 mg

    $275

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    Product Description

    AZD 1390 is an inhibitor of Ataxia-telangiectasia mutated (ATM) kinase (IC50 = 0.78 nM).1 It is selective for ATM over Ataxia-telangiectasia and Rad3-related protein/kinase (ATR), PI3K, mammalian target of rapamycin (mTOR), and DNA protein kinase (DNA-PK; IC50s = >30, >12, >16, and >29.9 µM, respectively). AZD 1390 (10 nM) sensitizes glioma cells expressing mutant, but not wild-type, p53 to ionizing radiation. Oral administration of AZD 1390 (20 mg/kg twice daily), in combination with radiation, reduces the growth of brain metastases and increases survival in an NCI H2228 lung carcinoma mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Durant, S.T., Zheng, L., Wang, Y., et al. The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci. Adv. 4(6), eaat1719 (2018).