A β1-AR antagonist
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Labeled Version(s)
35557Acebutolol-d7
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Acebutolol

Item No. 36534

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-butanamide
CAS Number
37517-30-9
Synonyms
  • M&B 17803A
Molecular Formula
C18H28N2O4
Formula Weight
336.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 5 mg/mLEthanol: 5 mg/mLPBS (pH 7.2): 0.3 mg/mL
SMILES
O=C(CCC)NC1=CC=C(C(C(C)=O)=C1)OCC(CNC(C)C)O
InChi Code
InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
InChi Key
GOEMGAFJFRBGGG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    250 mg

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    500 mg

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    Product Description

    Acebutolol is an antagonist of β1-adrenergic receptors (β1-ARs; Ki = 125 nM).1 It is selective for β1- over β2-ARs (Ki = 7,070 nM). In vivo, acebutolol decreases isoprenaline-induced tachycardia and diastolic hypotension in cats (ED50 = 0.09 mg/kg for both).2 Acebutolol (12.5, 25, and 50 mg/kg) inhibits ouabain-induced arrhythmias in rabbits, as well as protects against chloroform-induced ventricular fibrillation in mice (ED50 = 0.067 mg/kg).3 Formulations containing acebutolol have been used in the treatment of angina and irregular heartbeat.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsuchihashi, H., Nakashima, Y., Kinami, J., et al. Characteristics of 125I-iodocyanopindolol binding to β-adrenergic and serotonin-1B receptors of rat brain: Selectivity of β-adrenergic agents. Jpn. J. Pharmacol. 52(2), 195-200 (1990).

    2. Basil, B., Jordan, R., Loveless, A.H., et al. β-Adrenoceptor blocking properties and cardioselectivity of M & B 17,803A. Br. J. Pharmacol. 48(2), 198-211 (1973).

    3. Basil, B., Jordan, R., Loveless, A.H., et al. A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol. Br. J. Pharmacol. 50(3), 323-333 (1974).