A dual inhibitor of JAKs and Syk family kinases
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Gusacitinib

Item No. 36554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
CAS Number
1425381-60-7
Synonyms
  • ASN-002
Molecular Formula
C24H28N8O2
Formula Weight
460.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
267 nm
SMILES
N#CCC1CCN(CC1)C2=NC(C=NN3)=C(C(NC4=CC=C(N5CCC(CC5)O)C=C4)=N2)C3=O
InChi Code
InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)
InChi Key
NLFLXLJXEIUQDL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Gusacitinib is a dual inhibitor of JAKs (IC50s = 46, 4, and 11 nM for JAK1-3, respectively) and Syk family kinases (IC50s = 5 and 8 nM for SyK and TYK2, respectively).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bissonnette, R., Maari, C., Forman, S., et al. The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: Results from a randomized double-blind placebo-controlled study. Br. J. Dermatol. 181(4), 733-742 (2019).