A prodrug form of CPHPC
Related Products
Active Metabolite(s)
75500CPHPC
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Blood
Acute Phase Reactants

GSK3039294

Item No. 36559

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-(1,6-dioxo-1,6-hexanediyl)bis-D-proline, 2,2′-bis[[[[(tetrahydro-2H-pyran-4-yl)oxy]carbonyl]oxy]methyl] ester
CAS Number
1819986-22-5
Synonyms
  • GSK294
Molecular Formula
C30H44N2O14
Formula Weight
656.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C([C@@H]1N(C(CCCCC(N2[C@@H](C(OCOC(OC3CCOCC3)=O)=O)CCC2)=O)=O)CCC1)OCOC(OC4CCOCC4)=O
InChi Code
InChI=1S/C30H44N2O14/c33-25(31-13-3-5-23(31)27(35)41-19-43-29(37)45-21-9-15-39-16-10-21)7-1-2-8-26(34)32-14-4-6-24(32)28(36)42-20-44-30(38)46-22-11-17-40-18-12-22/h21-24H,1-20H2/t23-,24-/m1/s1
InChi Key
KSKLDMGKWDUQCT-DNQXCXABSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $76

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    10 mg

    $121

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    25 mg

    $285

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    Product Description

    GSK3039294 is a prodrug form of CPHPC (Item No. 75500), an inhibitor of the protein-protein interaction between serum amyloid P (SAP) and amyloid fibrils.1 It is converted to CPHPC by hydrolysis via a monoester intermediate in rat, canine, and human liver microsomes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Richards, D., Bamford, M., Liefaard, L., et al. Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap. Br. J. Pharmacol. 177(8), 1853-1864 (2020).